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HHV‐6‐related secondary graft failure following allogeneic bone marrow transplantation
Author(s) -
Johnston Rosalynd E.,
Geretti AnnaMaria,
Prentice H. Grant,
Clark A. Duncan,
Wheeler Anne C.,
Potter Michael,
Griffiths Paul D.
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01443.x
Subject(s) - foscarnet , medicine , ganciclovir , aplasia , bone marrow aplasia , bone marrow , bone marrow transplantation , transplantation , surgery , immunology , human cytomegalovirus , virus
We report the case of an 11‐year‐old boy who underwent allogeneic bone marrow transplantation (BMT) for relapsed acute lymphoblastic leukaemia. Despite adequate engraftment, on day 45 he developed marrow aplasia with haemophagocytosis. HHV‐6 was detected in blood and bone marrow by nested PCR. Retrospective testing showed that viraemia had started on day 24. Following therapy with foscarnet and ganciclovir, viral load declined to undetectable levels and his donor marrow recovered contemporaneously. This case suggests that HHV‐6 may be a treatable cause of graft failure following BMT and provides clinical and virological evidence for the anti‐HHV‐6 activity of ganciclovir and foscarnet.