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A prospective study of risk‐adapted therapy for large cell non‐Hodgkin's lymphoma with VACOP‐B followed by high‐dose CBV and autologous progenitor cell transplantation for high‐risk patients in remission
Author(s) -
Stahel Rolf A.,
Jost Lorenz M.,
Kroner Thomas,
DommannScherrer Corina,
Maurer Robert,
Glanzmann Christoph,
Jacky Emanuel,
Pichert Gabriella,
Pestalozzi Bernhard,
Marincek Borut,
Sauter Christian,
Honegger Hanspeter
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01263.x
Subject(s) - medicine , etoposide , chemotherapy , transplantation , autologous stem cell transplantation , lymphoma , carmustine , cyclophosphamide , surgery , oncology , gastroenterology
Several centres reported a favourable outcome after high‐dose chemotherapy with autologous progenitor cell transplantation in selected patients with high‐risk large cell non‐Hodkgin's lymphoma in first remission. Based on these observations, we wanted to prospectively determine the outcome of a risk‐adapted therapy for patients with large cell lymphoma. Patients aged 60 years or less received 12 weeks of VACOP‐B chemotherapy. For high‐risk patients in remission this was immediately followed by high‐dose chemotherapy with cyclophosphamide, carmustine and etoposide and autologous progenitor cell transplantation. High‐risk criteria were defined before the establishment of the International Index and included large cell lymphoma stage III or IV or mediastinal large lymphoma with sclerosis stage II or higher, and the presence of bulky tumours and/or an elevated LDH. 89 patients fulfilled the clinical selection criteria and were entered onto this multicentre study. 82 patients were evaluable after confirmation of large cell histology by pathology review. Of these, 51 were considered to be in the low‐risk group and 31 in the high‐risk group. The 3‐year event‐free survival for all patients was 68%. The 3‐year event‐free survival was 76% for the low‐risk and 55% for the high‐risk group ( P = 0.061). Only 22/31 high‐risk patients were able to receive the high‐dose chemotherapy in first remission as intended. In conclusion, although our study demonstrated that a risk‐adapted therapy for large cell lymphoma could be safely administered, the potential impact on outcome of the strategy chosen here is likely to be small.