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Expression of vascular endothelial growth factor in sera and lymph nodes of the plasma cell type of Castleman's disease
Author(s) -
NISHI JUNICHIRO,
ARIMURA KIMIYOSHI,
UTSUNOMIYA ATAE,
YONEZAWA SUGURU,
KAWAKAMI KIYOSHI,
MAENO NOBUAKI,
IJICHI OSAMU,
IKARIMOTO NAOAKI,
NAKATA MASANORI,
KITAJIMA ISAO,
FUKUSHIGE TAKAHIKO,
TAKAMATSU HIDEO,
MIYATA KOICHIRO,
MARUYAMA IKURO
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01208.x
Subject(s) - lymph , pathology , plasma cell , pathogenesis , castleman disease , medicine , vascular endothelial growth factor , vascular endothelial growth factor c , lymph node , vascular endothelial growth factor a , vegf receptors , disease , cancer research , bone marrow
To evaluate the possible involvement of vascular endothelial growth factor (VEGF) in the pathogenesis of Castleman's disease, we studied VEGF levels in sera and supernatants of cultured lymph nodes from two patients with the plasma cell type of Castleman's disease, and analysed the expression of VEGF immunohistochemically in the lymph nodes. Clinically, one patient was classified as the localized type and the other as the multicentric type. Histologically, mature plasma cells and hyalinized vessels were prominent in the interfollicular region. The VEGF levels of the sera and the supernatants of cultured lymph nodes of both patients were higher than those of normal controls. VEGF was strongly expressed in plasma cells in the interfollicular region of the lymph nodes of both patients, but rarely in normal lymph nodes. Our results suggest that VEGF may be involved in the marked vascular proliferation in the interfollicular region of the lymph nodes of the plasma cell type of Castleman's disease.