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Periodic chronic myelogenous leukaemia: spectral analysis of blood cell counts and aetiological implications
Author(s) -
Fortin Pascal,
Mackey Michael C.
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01168.x
Subject(s) - etiology , chronic myelogenous leukemia , medicine , blood cell , immunology , leukemia , pathology
Of 24 published clinical reports of periodic chronic myelogenous leukaemia (PCML), 21 had sufficient data to analyse for periodicity, and 12 showed significant periodicity ( p 0.05) using the Lomb periodogram. Leucocyte oscillations had periods T ranging from 37 to 83 d. When data were also reported for platelets and reticulocytes there was no significant difference between their periods and those of the leucocytes. These data and their analysis provide strong circumstantial evidence for a haemopoietic stem cell origin of PCML. Namely, the known chromosomal changes in CML patients may, on occasion, also be accompanied by a destabilization resulting in an oscillatory efflux into the leucocyte, platelet and erythrocytic pathways.