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Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance
Author(s) -
Ackermann Jutta,
Meidlinger Petra,
Zojer Niklas,
Gisslinger Heinz,
Ludwig Heinz,
Huber Heinz,
Drach Johannes
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.01124.x
Subject(s) - monoclonal gammopathy of undetermined significance , fluorescence in situ hybridization , multiple myeloma , bone marrow , pathology , trisomy , aneuploidy , biology , staining , microbiology and biotechnology , clinical significance , centromere , monoclonal , monoclonal antibody , medicine , chromosome , antibody , immunology , gene , genetics
We have recently shown that presence of a p53 deletion in multiple myleoma is an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence in situ hybridization (FISH) with chromosome 17‐centromere and p53‐gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS.