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In vitro antisickling activity of cromolyn sodium
Author(s) -
Fall Ahmedou B. K.,
Toppet Michèle,
Ferster Alina,
Fondu Pierre,
VanhaelenFastré Renée,
Vanhaelen Maurice
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.01106.x
Subject(s) - cromolyn sodium , medicine , pharmacology , in vivo , in vitro , hemoglobinopathy , sodium , pentoxifylline , sickle cell anemia , hydroxycarbamide , chemistry , chemotherapy , biochemistry , hemolytic anemia , disease , biology , microbiology and biotechnology , organic chemistry , asthma
The improvement in sickle cell disease (SCD) children receiving cromolyn sodium therapy prompted us to investigate its antisickling activity in vitro . The number of sickle cells was determined in deoxygenated blood samples from 15 children with severe SCD. At the eight concentrations tested, cromolyn sodium exhibited a significantly higher activity than pentoxifylline, the standard compound. Therefore cromolyn sodium would appear to be an interesting candidate for SCD therapy and deserves further in vivo investigations.