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Successful adoptive immunotherapy for relapse of AML 9 years after T‐cell‐depleted BMT
Author(s) -
Bertz Hartmut,
Kunzman Regine,
Bunjes Donald,
Finke JÜrgen
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.01007.x
Subject(s) - buffy coat , adoptive immunotherapy , medicine , transplantation , immunotherapy , immunology , adoptive cell transfer , immune system , t cell
Relapse is one of the main problems which can occur following allogeneic transplantation for haematological malignancies. In this situation the enhancement of the graft‐versus‐leukaemia effect by transfusion of donor buffy coats with or without cytokines may lead to complete remission especially in myeloid leukaemias. FISH (fluorescence in situ hybridization) is a sensitive method to monitor chimaerism in gender‐different transplantation. We report a case of successful buffy coat transfer therapy > 9 years after bone marrow transplanation. This is the longest interval reported, to our knowledge, between transplantation to relapse, which was treated by adoptive immunotherapy. Complete donor chimaerism was confirmed by FISH.