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Apparent reactivation of a red cell alloantibody in a healthy individual after G‐CSF administration
Author(s) -
Norol,
Vincent Bonin,
Charpentier,
Bierling,
beaujean,
Cartron,
Bories,
Kuentz
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00950.x
Subject(s) - medicine , granulocyte colony stimulating factor , immunology , adverse effect , transplantation , concomitant , antigen , immune system , granulocyte , isoantibodies , stem cell , chemotherapy , biology , genetics
Granulocyte‐colony stimulating factor (G‐CSF) has been successfully administered to healthy subjects to mobilize peripheral blood stem cells (PBSC) for allogeneic transplantation. Adverse events are moderate. We report the first case of apparent reactivation of an alloantibody to a blood cell antigen (Jk a ) after G‐CSF administration to a healthy subject and its transmission to the PBSC transplant recipient; no concomitant reactivation of other alloantibodies was detected. This case raises questions on the effect of G‐CSF on the immune system and its safety in healthy individuals.