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Conservative management of follicular non‐Hodgkin's lymphoma in childhood
Author(s) -
Ayad Atra,
S Meller,
Robert S. Stevens,
Rachel Hobson,
R Grundy,
R L Carter,
CR Pinkerton
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00941.x
Subject(s) - medicine , follicular lymphoma , lymphoma , chemotherapy , stage (stratigraphy) , presentation (obstetrics) , surgery , follicular phase , regimen , pediatrics , gastroenterology , paleontology , biology
Among 447 children with non‐Hodgkin's lymphoma (NHL) on the childhood U.K. registry, seven children with follicular (NHL) were identified. Four were male and their age ranged from 4.25 to 13.5 years (median 7.5); all had localized disease, Murphy's stage I ( n = 4) and II ( n = 3). Sites involved at presentation were cervical lymph nodes and tonsils ( n = 5), ileum ( n = 1) and parotid gland ( n = 1). Three had complete surgical excision only and four had complete ( n = 1) or incomplete excision ( n = 3) followed by a short multi‐agent chemotherapy regimen (UKCCSG 9001 protocol). With a median follow‐up of 1.5 years (range 0.25–5 years) from diagnosis, six are alive in complete remission (CR) including three who had no chemotherapy. These results confirm previous reports that follicular lymphomas in children are rare (1.5%) and tend to be localized at presentation. Their rarity makes it difficult to produce guidelines about treatment, but in localized cases a period of non‐intervention may be justified.