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CD20‐positive T‐cell chronic lymphocytic leukaemia
Author(s) -
Takami Akiyoshi,
Saito Masanori,
Nakao Shinji,
Asakura Hidesaku,
Nozue Tsuyoshi,
Onoe Yoshihito,
Yachie Akihiro,
Shiobara Shintaro,
Matsuda Tamotsu
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00884.x
Subject(s) - cd5 , t cell receptor , antigen , cd20 , cd8 , biology , cd19 , gene rearrangement , cd38 , cd3 , immunology , t cell , microbiology and biotechnology , gene , immune system , genetics , cd34 , stem cell
Although CD20 is considered to be a representative marker for B lymphocytes, the antigen is weakly expressed on a small subset of normal T lymphocytes. A 60‐year‐old man developed pancytopenia and hepatosplenomegaly due to clonal proliferation of atypical lymphocytes that were weakly positive for CD20. The leukaemic cells were also positive for T‐cell antigens such as CD2, CD3, CD5, CD7, CD8 and T‐cell receptor (TCR) Vβ8 and for activation antigens such as CD38 and HLA‐DR, but were negative for CD19, CD21, CD22, CD25. Southern blot analysis revealed rearrangement of the TCR‐β gene and a germline configuration of the immunoglobulin heavy chain gene. This is the first report of a case of clonal expansion of CD20dim Tlymphocytes