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Serum levels of p55 and p75 soluble TNF receptors in adult acute leukaemia at diagnosis: correlation with clinical and biological features and outcome
Author(s) -
Vinante Fabrizio,
Rigo Antonella,
Tecchio Cristina,
Morosato Lorella,
Nadali Gianpaolo,
Ricetti Maria Maddalena,
Krampera Mauro,
Zanolin Elisabetta,
Locatelli Francesca,
Gallati Harald,
Chilosi Marco,
Pizzolo Giovanni
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00872.x
Subject(s) - medicine , myeloid leukaemia , receptor , tumor necrosis factor alpha , myeloid , in vivo , gastroenterology , immunology , biology , microbiology and biotechnology
The tumour necrosis factor (TNF)/TNF‐receptor (TNFR) complex plays a role in the growth of leukaemic cells. We retrospectively investigated the relationship between pre‐treatment serum concentration of soluble TNFR (p55‐ and p75‐sTNFRs) and outcome in adult acute myeloid (AML 82 cases) and lymphoid (ALL 44 cases) leukaemia. Both sTNFRs were significantly higher in AML (p55‐sTNFR 4.53 ± 3.7, median 3.75; p75‐sTNFR 6.51 ± 5.25 ng/ml, median 4.72) and ALL sera (3.31 ± 1.5, median 2.95; 5.30 ± 2.3 ng/ml, median 4.56, respectively) than in controls (1.89 ± 0.5, median 1.98; 2.22 ± 0.8 ng/ml, median 2.37) ( P < 0.01 for both sTNFRs). Fresh leukaemic cells expressed p55‐ and p75‐sTNFRs, which were modulated and released into the supernatant (SN) following short‐term in vitro culture, suggesting that in vivo sTNFRs were also leukaemia‐derived. Whereas no correlation was observed between sTNFRs and outcome in ALL, in AML higher p55‐sTNFR levels (> 3.75 ng/ml) were associated with shorter disease‐free survival (DFS) ( P = 0.006) and overall survival (OS) ( P = 0.0004). At multivariate analysis p55‐sTNFR was the most significant predictor of DFS ( P = 0.006) and OS ( P < 0.001). Our data suggest that the prognostic significance of p55‐sTNFR in AML could be related to relevant biological features of AML blasts.