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Multiple myeloma and the translocation t(11;14)(q13;q32): a report on 13 cases
Author(s) -
Fonseca Rafael,
Witzig Thomas E.,
Gertz Morie A.,
Kyle Robert A.,
Hoyer James D.,
Jalal Syed M.,
Greipp Philip R.
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00700.x
Subject(s) - chromosomal translocation , multiple myeloma , abnormality , bone marrow , peripheral blood mononuclear cell , medicine , pathology , cytogenetics , gastroenterology , monoclonal gammopathy of undetermined significance , clinical significance , chromosome abnormality , karyotype , immunology , biology , chromosome , monoclonal , antibody , monoclonal antibody , genetics , psychiatry , gene , in vitro
Complex cytogenetic abnormalities have been described in patients with multiple myeloma (MM). To better understand the significance of the most frequent translocation observed in MM, we studied the clinical characteristics of patients with MM and the t(11;14)(q13;q32) abnormality. A search of the cytogenetic database at the Mayo Clinic identified patients with MM and t(11;14)(q13;q32). The medical records were reviewed for the clinical characteristics of these patients. We identified 13 patients with MM and t(11;14)(q13;q32) determined by standard cytogenetic analysis; in 10 patients the abnormality was detected at the time of relapse (three with previously normal results of cytogenetic examination). At the time the translocation was detected, plasma cell (PC) leukaemia was clinically diagnosed in two patients. The median number of circulating PCs, as determined by the cytoplasmic immunofluorescence of T‐cell‐depleted peripheral blood mononuclear cells, was 1.1 × 10 9 /l (mean 1.74; range 0.0017–6.26 × 10 9 /l). On linear regression analysis there was a strong correlation between the number of circulating PCs and the number of bone marrow PCs. The median survival after demonstration of the translocation was 8.1 months. Of all patients, 10 died of disease progression and three were alive. Patients with MM who have t(11;14)(q13;q32) seem to have an aggressive clinical course, even when the abnormality is detected at the time of diagnosis, with evidence of many circulating PCs.