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CD3 − CD4 − CD8 − CD56 − CD19 − CD14 − cells and CD3 + CD8 dull‐positive cells produce IL‐4 in AIDS patients
Author(s) -
Honda Junichi,
Okubo Yasumitsu,
Tanaka Ken,
Kusaba Mikako,
Kumagai Mutsuko,
Saruwatari Naoko,
Oizumi Kotaro
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00647.x
Subject(s) - cd19 , cd8 , cd3 , cytotoxic t cell , immunology , cd14 , interleukin 21 , immune system , biology , medicine , in vitro , biochemistry
We used flow cytometry to identify the presence of intracellular cytokines (cytoflow) and analyse the production of IL‐4 in peripheral blood from AIDS patients who have practically no CD4 + T cells. We found that IL‐4 was produced by CD3 − CD4 − CD8 − CD56 − CD19 − CD14 − cells and CD3 + CD8 dull‐positive cells in AIDS patients. Moreover, CD3 − CD4 − CD8 − CD56 − CD19 − CD14 − cells had helper activity for immunoglobulin synthesis. These findings indicate that instead of CD4 + T helper cells, C3 − CD4 − CD8 − CD56 − CD19 − CD14 − cells and CD3 + CD8 dull‐positive cells may be an important source of IL‐4 in a variety of immune responses for AIDS patients.