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Familial acute myeloid leukaemia: four male members of a single family over three consecutive generations exhibiting anticipation
Author(s) -
Christopher Lord,
R Powles,
Jayesh Mehta,
Kate Wilson,
J. Treleaven,
S Meller,
Daniel Catovsky
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00607.x
Subject(s) - anticipation (artificial intelligence) , medicine , chemotherapy , disease , abnormality , myeloid leukaemia , bone marrow transplantation , myeloid , pediatrics , bone marrow , oncology , psychiatry , artificial intelligence , computer science
A kindred with familial acute myeloid leukaemia (AML) is described displaying the concept of anticipation which refers to increased disease severity and/or earlier age at onset with succeeding generations. The affected individual in the first generation was the father (aged 34 years at diagnosis) of two affected members of a single sibship (aged 24 and 25 years). The fourth patient is the son (aged 4 years) of one of these brothers in the second generation. The AML was of different subtypes and a karyotypic abnormality (del[6q]) was detected in one of three patients. The first‐generation patient died during chemotherapy; the remaining three patients are in complete remission after chemotherapy and autologous bone marrow transplantation.