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Norethisterone therapy for bleeding due to gastrointestinal telangiectases in Glanzmann's thrombasthenia
Author(s) -
Michael J. Leach,
Michael Makris,
K. K. Hampton,
F. E. Preston
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00601.x
Subject(s) - medicine , tranexamic acid , telangiectases , gastrointestinal bleeding , thrombasthenia , omeprazole , telangiectasia , glanzmann's thrombasthenia , platelet transfusion , surgery , platelet , gastroenterology , blood loss , platelet aggregation
We report a case of a patient with Glanzmann's thrombasthenia and anti‐GPIIb/IIIa alloantibodies who developed life‐threatening and intractable bleeding from gastrointestinal telangiectatic lesions. After a period of transfusion‐dependent gastrointestinal bleeding despite tranexamic acid, oral iron, omeprazole and platelet transfusions, the use of oral norethisterone produced a significant improvement with a marked reduction in her transfusion requirements.