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Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant
Author(s) -
Coulthard Stephanie,
Chase Andrew,
Orchard Kim,
Watmore Ann,
Vora Ajay,
Goldman John M.,
Swirsky David M.
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00587.x
Subject(s) - chromosomal inversion , breakpoint , myeloid , cytogenetics , karyotype , biology , myeloid leukaemia , chromosome , genetics , gene , bone marrow , cancer research , pathology , medicine , immunology
We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasize the importance of the breakpoint at 8p11 and the possible involvement of the MOZ gene in all these cases.