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Serum thrombopoietin levels in Kawasaki disease
Author(s) -
Miura Nobuyuki,
Terai Masaru,
Meng Y. Gloria,
Sato Takeyuki,
Niimi Hiroo
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00584.x
Subject(s) - thrombocytosis , medicine , kawasaki disease , thrombopoietin , platelet , thrombosis , gastroenterology , myocardial infarction , systemic disease , immunology , disease , artery , stem cell , haematopoiesis , biology , genetics
Kawasaki disease (KD) is an acute febrile vasculitic syndrome with thrombocytosis occurring in childhood. Transient thrombocytosis of KD is sometimes the cause of complications such as coronary aneurysmal thrombosis and myocardial infarction. We have analysed blood TPO levels in KD and found that 26/31 acute‐phase KD patients had detectable blood TPO levels (mean 173 pg/ml; range 89–294 pg/ml), which decreased immediately with the elevation of platelet counts in 5/12 patients studied. Elevated serum level of TPO may have an important role for this ill‐defined disease.