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Renin in acute myeloid leukaemia blasts
Author(s) -
Wulf Gerald G.,
JahnsStreubel Gerlinde,
Nobiling Rainer,
Strutz Frank,
Hemmerlein Bernhard,
Hiddemann Wolfgang,
Wörmann Bernhard
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00565.x
Subject(s) - bone marrow , renin–angiotensin system , medicine , myeloid , stromal cell , pathology , immunology , cancer research , blood pressure
Hypokalaemia is a clinical phenomenon in patients with acute myeloid leukaemia (AML) to which activation of the renin–angiotensin system (RAS) may contribute. Recently monocytes were found to express renin, the key initializing enzyme of the RAS. By RT/PCR, transcripts for renin were detected in four of 18 bone marrow samples from patients with AML. Three leukaemic cell lines, isolated monocytes, bone marrow stromal cells and 25 peripheral blood and 24 bone marrow samples of normal controls were negative for renin transcripts. In view of the importance of local RAS in other tissues, the expression of renin in the bone marrow of AML patients warrants further investigation.