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Large granular lymphocytic leukaemia with a mixed T‐cell/B‐cell phenotype
Author(s) -
Akashi Koichi,
Shibuya Tsunefumi,
Nakamura Minoru,
Oogami Akiko,
Harada Mine,
Niho Yoshiyuki
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00552.x
Subject(s) - cd5 , biology , cd8 , b cell , immunology , antibody , phenotype , microbiology and biotechnology , genetics , gene , antigen
We report a case of large granular lymphocytic leukaemia (LGLL) with mixed T‐cell/B‐cell phenotypes. The LGLL cells expressed T‐cell markers such as CD1, CD2, CD3, CD5, CD7, CD8 and CD57. The CD8 + LGLL cells coexpressed B‐cell markers including CD20 and PCA‐1, and a fraction of purified CD8 + LGLL cells secreted double isotypes of immunoglobulins (IgG‐κ and IgA‐κ). Both TCRB and IGH genes were clonally rearranged. The LGLL cells could be divided into at least three subpopulations that were cytogenetically distinct, and all subpopulations involved the 11q23. The expression of both T‐ and B‐cell markers on the LGLL cells suggests the involvement of a putative common lymphoid progenitor in leukaemic transformation.