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Increased number of peripheral blood CD34 + cells in lithium‐treated patients
Author(s) -
Ballin Ami,
Lehman Dan,
Sirota Pinkhas,
Litvinjuk Ulia,
Meytes Dina
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00537.x
Subject(s) - cd34 , peripheral blood , lithium carbonate , lithium (medication) , peripheral , transplantation , medicine , urology , immunology , andrology , chemistry , gastroenterology , stem cell , biology , ion , genetics , organic chemistry , ionic bonding
Eight adult patients with bipolar disorder were prospectively examined to find whether lithium carbonate increased their peripheral blood CD34 + haemopoietic stem cells. Following lithium therapy for 3–4 weeks their neutrophil counts increased by a mean of 88% (from 4625 ± 1350 × 10 9 /l, mean ± SD pretreatment, to a peak of 8300 ± 3910 × 10 9 /l). Concommitantly, there was a significant increment in their CD34 + cells (from 0.11 ± 0.01% to a peak of 0.18 ± 0.08%). There was a significant correlation between the rise in neutrophil count and that of the CD34 + cells ( r = 0.795, P = 0.019). Lithium therapy may be used to mobilize peripheral blood CD34 + cells for marrow transplantation.