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A lymphohistiocytic variant of anaplastic large cell lymphoma with demonstration of the t(2;5)(p23;q35) chromosome translocation
Author(s) -
Ott German,
Bastian Boris C.,
Katzenberger Tiemo,
Decoteau John F.,
Kalla Jörg,
Rosenwald Andreas,
Weissinger Florian,
Ott M. Michaela,
Kadin Marshall E.,
MüllerHermelink Hans K.
Publication year - 1998
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1998.00531.x
Subject(s) - chromosomal translocation , anaplastic large cell lymphoma , cd30 , lymphoma , cytogenetics , anaplastic lymphoma kinase , biology , molecular cytogenetics , lymph node , pathology , biopsy , lymph node biopsy , large cell , cancer research , chromosome , microbiology and biotechnology , medicine , genetics , gene , cancer , adenocarcinoma , malignant pleural effusion , lung cancer
Cytogenetic investigations were performed in a case of a nodal malignant non‐Hodgkin's lymphoma. Histopathological analysis from an involved lymph node as well as from a skin biopsy revealed a lymphohistiocytic variant of CD30‐positive anaplastic large cell lymphoma (ALCL). A t(2;5)(p23;q35) chromosome translocation could be observed in all metaphases analysed. This finding was confirmed both by RT‐PCR analysis of the NPM/ALK fusion protein and by positive staining with the p80 NPM/ALK antibody. To the best of our knowledge, this is the first report of a t(2;5) documented by classic cytogenetics in the lymphohistiocytic variant of ALCL.