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Long‐term effects of localized spinal radiation therapy on vertebral fractures and focal lesions appearance in patients with multiple myeloma
Author(s) -
LECOUVET FREDERIC,
RICHARD FRANC¸OISE,
BERG BRUNO VANDE,
MALGHEM JACQUES,
MALDAGUE BAUDOUIN,
JAMART JACQUES,
FERRANT AUGUSTIN,
MICHAUX JEANLOUIS
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.d01-2108.x
Subject(s) - medicine , multiple myeloma , magnetic resonance imaging , lumbar vertebrae , radiation therapy , bone marrow , radiology , vertebra , thoracic vertebrae , spinal cord , lumbar , pathology , anatomy , psychiatry
The occurrence of new vertebral fractures and focal marrow lesions was determined and compared in irradiated and nonirradiated vertebrae of 12 patients with multiple myeloma (MM), prospectively followed using magnetic resonance imaging (MRI) of the thoraco‐lumbar spine after localized spinal radiation therapy. During follow‐up (mean 35 months), fractures appeared in 5% of irradiated vertebrae and in 20% of nonirradiated vertebrae; new focal lesions appeared in 4% of irradiated vertebrae and in 27% of nonirradiated vertebrae. This study demonstrates a beneficial long‐term effect of localized radiation therapy, consisting of a reduced incidence of vertebral fractures and focal marrow lesions in irradiated vertebrae.