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Reliability of delayed INR determination: implications for decentralized anticoagulant care with off‐site blood sampling
Author(s) -
Baglin Trevor,
Luddington Roger
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.d01-2079.x
Subject(s) - medicine , anticoagulant , blood sampling , significant difference , workload , mean difference , emergency medicine , surgery , confidence interval , computer science , operating system
In order to develop decentralized anticoagulant care by off‐site blood sampling and transport of samples to a centralized laboratory for International Normalized Ratio (INR) determination we have performed a direct comparative study of INR stability. Analysis was performed daily for 5 d using nine thromboplastins. The overall mean difference of INR after 3 d was only 0.05 INR units for samples with a therapeutic INR. After 5 d there was a mean difference of 0.11 INR units with ‘non‐Manchester’ reagents and 0.44 INR units with ‘Manchester’ reagents. With over‐anticoagulated samples mean differences of 0.55–0.72 INR units were observed after 3 d and 1.16–2.46 INR units after 5 d. Although there was some variation in stability of results with different thromboplastins, the difference over time with each thromboplastin was much less than the difference between thromboplastins. In conclusion, there is no clinically significant change in INR when analysis is delayed for up to 3 d. Off‐site blood sampling can accommodate a large increase in patient workload without a major revenue increase in primary care and with continued total quality management and central expert advice.