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Peripheral blood stem cell apheresis in normal donors: feasibility and yield of second collections
Author(s) -
Anderlini P.,
Lauppe J.,
Przepiorka D.,
Seong D.,
Champlin R.,
Ko¨rbling M.
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.d01-2013.x
Subject(s) - apheresis , filgrastim , medicine , peripheral blood , adverse effect , transplantation , confidence interval , granulocyte colony stimulating factor , surgery , platelet , chemotherapy
We report 13 normal peripheral blood stem cell (PBSC) donors who had a second PBSC collection for allogeneic transplantation performed after the first. The median interval between the first and second collection was 5 months. Mobilization was achieved with filgrastim (12 μg/kg/d). No significant difference was found in the median pre‐apheresis leucocyte count (×10 9 /l) between the two donations (40.2 v 38.5; P = 0.91). The median apheresis yield (×10 6 CD34 + cells/litre blood processed, first apheresis) was also similar (28 v 27.3; P = 0.91). Filgrastim‐related adverse events were comparable. These data suggest that second PBSC collections are feasible, similarly tolerated and provide comparable apheresis yields.