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PTHrP‐mediated hypercalcaemia in a case of CML blast crisis
Author(s) -
KUBONISHI ICHIRO,
ASAHI YASUTOMO,
MACHIDA HISANORI,
UEMURA YOSHIKI,
HATAKEYAMA NOBUO,
KUBOTA TETSUYA,
OHTSUKI YUJI,
MIYOSHI ISAO
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.d01-1985.x
Subject(s) - hypercalcaemia , parathyroid hormone related protein , blast crisis , transplantation , medicine , in vitro , cancer research , parathyroid hormone , endocrinology , calcium , chemistry , bone marrow , biochemistry
We report a 52‐year‐old man with chronic myelogenous leukaemia (CML) who developed hypercalcaemia in blast crisis. There was a high serum level of parathyroid hormone‐related protein (PTHrP). The leukaemia cells secreted PTHrP into culture medium when cultured in vitro and were shown to express PTHrP mRNA by reverse transcription‐polymerase chain reaction. Transplantation of the leukaemia cells into nude mice resulted in the production of Ph 1 chromosome‐positive tumours which caused increased levels of calcium and PTHrP in the blood. These results indicated that the hypercalcaemic event in the patient was induced by PTHrP of CML cell origin.