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Evolution of blood coagulation and fibrinolysis parameters after abrupt versus gradual withdrawal of acenocoumarol in patients with venous thromboembolism: a double‐blind randomized study
Author(s) -
Tardy Bernard,
TardyPoncet Brigitte,
LaporteSimitsidis Silvy,
Mismetti Patrick,
Decousus Hervé,
Guyotat Denis,
Bertrand Jean C.
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.8752506.x
Subject(s) - acenocoumarol , fibrinolysis , medicine , anesthesia , randomized controlled trial , coagulation , significant difference , double blind , gastroenterology , warfarin , placebo , atrial fibrillation , alternative medicine , pathology
A double‐blind randomized trial was conducted to research a hypercoagulable state rebound after abrupt versus gradual withdrawal of acenocoumarol. 20 patients were included: 10 in the abrupt withdrawal group (AW) and 10 in the gradual withdrawal group (GW). Between days 1 and 15, F1+2 was higher in group AW ( P <0.002). A sig‐nificant increase of D‐dimer with time was found ( P <0.001) without difference between the two groups. tPA and PAI‐1 levels remained stable throughout without difference between the two groups. No rebound phenomenon was observed. Four thrombotic recurrences were observed: group AW: 1, group GW: 3 ( P =0.29). There is neither clinical nor biological support for a gradual anticoagulation withdrawal.