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Angina pectoris occurring during granulocyte colony‐stimulating factor‐combined preparatory regimen for autologous peripheral blood stem cell transplantation in a patient with acute myelogenous leukaemia
Author(s) -
Fukumoto Yumiko,
Miyamoto Toshihiro,
Okamura Takashi,
Gondo Hisashi,
Iwasaki Hiromi,
Horiuchi Takahiko,
Yoshizawa Shigeru,
INABA SOICHI,
Harada Mine,
Niho Yoshiyuki
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.842724.x
Subject(s) - medicine , angina , granulocyte colony stimulating factor , neutrophilia , transplantation , stem cell , aspirin , regimen , immunology , chemotherapy , myocardial infarction , biology , genetics
We describe a patient with acute myelogenous leukaemia who developed angina pectoris during pre‐transplant conditioning for autologous peripheral blood stem cell transplantation (PBSCT); the conditioning regimen consisted of cytotoxic drugs in combination with granulocyte colony‐stimulating factor (G‐CSF). Neutrophilia and hypercoagulability were observed at the time of angina pectoris. Recurrence of angina pectoris was not seen after nitrate and aspirin therapy. Exercise stress testing performed after PBSCT suggested the presence of myocardial ischaemia. Therefore cases at risk of vascular events should be carefully managed with prophylactic treatment during G‐CSF administration.