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Clonal chromosomal abnormalities as direct evidence for clonality in nasal T/natural killer cell lymphomas
Author(s) -
TIEN HWEIFANG,
SU IHJEN,
TANG JIHLUH,
LIU MINGCHI,
LEE FENYU,
CHEN YAOCHANG,
CHUANG SOUMING
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.752711.x
Subject(s) - isochromosome , lymphoma , biology , immunology , natural killer cell , pathology , gene rearrangement , chromosome 12 , t cell lymphoma , chromosome , cancer research , karyotype , genetics , gene , medicine , cytotoxicity , in vitro
Nasal T/natural killer (NK) cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe. The clonal nature of the infiltrating lymphoid cells is difficult to demonstrate because of the lack of immunologic markers for clonality and the absence of clonal T‐cell receptor gene rearrangement in most cases. In this study, clonal chromosomal abnormalities were detected in the tumour cells from four patients with nasal T/NK cell lymphoma. This finding provided direct evidence for clonality of the disease. Moreover, nonrandom cytogenetic abnormalities, including isochromosome for the short arm (p) of chromosome 6, isochromosome for the long arm (q) of chromosome 1, partial deletion of 6q, and aberrations at 11q, were disclosed. Isochromosome 6p was the sole structural abnormality in one patient, which may be a pathognomonic change in nasal lymphoma.