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Thrombotic thrombocytopenic purpura in a patient with genetic haemochromatosis, liver cirrhosis and an iron‐free focus
Author(s) -
Killick S.,
Jeffery S.,
Otter M.,
Rist C.,
Bevan D.
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.4873293.x
Subject(s) - cirrhosis , hemochromatosis , medicine , liver biopsy , thrombotic thrombocytopenic purpura , gastroenterology , biopsy , mutation , pathology , platelet , gene , biology , genetics
We report a patient with thrombotic thrombocytopenic purpura and genetic haemochromatosis. The patient was shown by the polymerase chain reaction to be homozygous for the Cys282Tyr mutation of the HFE gene. Liver biopsy showed micronodular cirrhosis and the presence of an iron‐free focus which was thought to be pre‐neoplastic.