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G‐CSF after peripheral blood stem cell transplantation in lymphoma patients significantly accelerated neutrophil recovery and shortened time in hospital: results of a randomized BNLI trial
Author(s) -
Linch David C.,
Milligan Donald W.,
Winfield David A.,
Kelsey Stephen M.,
Johnson Stephen A.,
Littlewood Timothy J.,
Smith Graeme M.,
Hutchinson Robert M.,
Goldstone Anthony H.,
Fielding Adele K.,
Vaughan Hudson Gillian
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.4703274.x
Subject(s) - medicine , granulocyte colony stimulating factor , transplantation , surgery , regimen , cyclophosphamide , chemotherapy , gastroenterology
We have undertaken a prospective randomized study in 90 patients with relapsed or resistant lymphomas to assess the value of G‐CSF (lenograstim) in the acceleration of myeloid recovery after peripheral blood stem cell transplantation (PBSCT). A common regimen of cyclophosphamide 1.5 g/m 2 on day 1 and lenograstim 263 μg s.c. on days 2–10 with two aphereses on days 10 and 11 was used for stem cell mobilization. 77% of patients achieved an adequate PBSC collection in two harvests (>2 × 10 8 MNC/kg or >2 × 10 6 CD34 + cells/kg). 65 patients went on to receive high‐dose BEAM chemotherapy and engraftment data was available for 62. 34 patients had been randomized to receive lenograstim 263 μg/d s.c. and 28 to no growth factor. The median time to ANC > 0.5 × 10 9 /l was 9 d in the lenograstim arm versus 12.5 d in the no‐lenograstim arm ( P = 0.0001). This was associated with a median duration of time in hospital post PBSCT of 13 d in the lenograstim arm versus 15.5 d in the no‐lenograstim arm ( P = 0.0002). Median days to platelet independence, platelet transfusions, incidence of infection and red cell transfusion were the same in both arms. These data indicate that lenograstim significantly accelerated myeloid recovery after PBSCT and shortened the duration of hospital stay.