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Clotting factor IX levels in C/EBPα knockout mice
Author(s) -
Davies N.,
Austen D. E. G.,
Wilde M. D.,
Darlington G. J.,
Brownlee G. G.
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.4603263.x
Subject(s) - factor ix , clotting factor , knockout mouse , medicine , immunology , endocrinology , receptor
Previous studies have indicated that C/EBPα is involved in the regulation of factor IX and mutations of a C/EBP recognition element in the factor IX promoter result in haemophilia B. We now report that mice homozygous for the deletion of the c/ebpα gene are significantly deficient in factor IX transcription.