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T cells selectively infiltrate bone marrow areas with residual haemopoiesis of patients with acquired aplastic anaemia
Author(s) -
Mlenhorst J. Joseph,
Van Krieken Johan H. J. M.,
Dreef Enno,
Landegent James E.,
Willemze Roel,
Fibbe Willem E.
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.4353245.x
Subject(s) - pancytopenia , bone marrow , aplastic anemia , haematopoiesis , medicine , infiltration (hvac) , pathology , cd3 , immunohistochemistry , stem cell , immunology , biology , immune system , cd8 , physics , genetics , thermodynamics
Aplastic anaemia (AA) is characterized by pancytopenia and bone marrow (BM) hypocellularity. In some patients AA may be mediated by T cells. To localize inflammatory cell infiltrates, we carried out a quantitative immunohistochemical analysis of BM biopsies of AA patients. In five out of eight biopsies, significantly higher numbers T cells were found in the areas with residual haemopoiesis (RH). The significantly increased numbers of CD3 + T cells in areas with RH supports the hypothesis of a site‐directed infiltration and/or a local proliferation of T cells in the BM of patients with AA.