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Potential salvage therapy for inadvertent intrathecal administration of vincristine
Author(s) -
Michelagnoli M. P.,
Bailey C. C.,
Wilson I.,
Livingston J.,
Kinsey S. E.
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.3693183.x
Subject(s) - vincristine , medicine , intrathecal , neurological deficit , administration (probate law) , salvage therapy , surgery , anesthesia , chemotherapy , intensive care medicine , cyclophosphamide , law , political science
Vincristine is an anti‐neoplastic agent for intravenous use. Inadvertent intrathecal administration of vincristine tends to follow a predictable clinical sequence of a progressive ascending radiculomyeloencephalopathy, usually fatal in outcome. We report a case of a 10‐year‐old girl who suffered an inadvertent intrathecal vincristine administration. We have outlined the management strategy used and her consequent neurological progress. She has survived but with a significant neurological deficit. Her outcome is, however, less severe than in previous literature reports; this may in part be attributable to early aggressive neurological management. This case also serves to highlight the tragic consequences of human error when handling chemotherapeutic agents of this nature.