Premium
Sibling allogeneic bone marrow transplantation in a patient with type I Glanzmann's thrombasthenia
Author(s) -
McColl M. D.,
Gibson B. E. S.
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.3533167.x
Subject(s) - glanzmann's thrombasthenia , thrombasthenia , medicine , sibling , mucocutaneous zone , dyskeratosis congenita , bone marrow , platelet disorder , surgery , platelet , pediatrics , disease , platelet aggregation , genetics , psychology , dna , developmental psychology , telomere , biology
Glanzmann's thrombasthenia is a rare inherited bleeding disorder caused by either quantitative or qualitative abnormalities of the platelet membrane glycoprotein (Gp) IIb/IIIa complex. Bleeding is usually mucocutaneous in origin and may be of a severe nature. We report the use of allegeneic bone marrow transplantation in a 5‐year‐old child with homozygous type I Glanzmann's thrombasthenia, using the patient's younger brother as marrow donor. Engraftment was successful and has resulted in a resolution of bleeding episodes. We conclude that allogeneic BMT is a potentially curative option for those with Glanzmann's thrombasthenia associated with severe bleeding symptoms.