Premium
Fludarabine is effective in the treatment of splenic lymphoma with villous lymphocytes
Author(s) -
Bolam Simon,
Orchard Jenny,
Oscier David
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.3523168.x
Subject(s) - fludarabine , medicine , lymphoma , salvage therapy , gastroenterology , oncology , chemotherapy , surgery , cyclophosphamide
We report on the use of fludarabine in four patients with splenic lymphoma with villous lymphocytes (SLVL). All four had relapsed after, or failed to respond to, recommended first‐line therapies. In each case fludarabine resulted in a complete clinico‐haematological response with minimal toxicity, which, in the two patients with long‐term follow‐up, proved durable. Fludarabine is effective in the treatment of SLVL and should be considered as both a first‐line therapeutic option as well as salvage therapy in this condition.