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Expression of several members of the TNF‐ligand and receptor family on tonsillar lymphoid B cells
Author(s) -
Dürkop Horst,
Anagnostopoulos Ioannis,
BulfonePaus Silvia,
Stein Harald
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.3153134.x
Subject(s) - flow cytometry , cd40 , peripheral blood mononuclear cell , tumor necrosis factor alpha , biology , receptor , lymphatic system , cd30 , ligand (biochemistry) , microbiology and biotechnology , pathology , immunology , immunohistochemistry , medicine , cytotoxic t cell , in vitro , biochemistry
Although the expression patterns of the members of the tumour necrosis factor receptor and ligand families have extensively been studied by flow‐cytometry on stimulated peripheral blood mononuclear cells (PBMNC), little or no flow‐cytometric or immunohistological data exist about their expression in lymphoid tissue. According to the data obtained from stimulated PBMNC, several members of these molecule families (e.g. CD40 ligand [CD40L], CD30, CD27, hOX40) have been considered to be either T‐cell restricted or strongly T‐cell associated. The present study on samples from palatine tonsils revealed that most of these molecules are also expressed by tonsillar B cells. The additional analysis of the co‐expression of these molecules also disclosed the existence of CD40 + /CD40L + and CD27 + /CD70 + (CD27L + ) lymphoid cells in tonsillar tissue.