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Alpha interferon gene deletions in post‐transplant lymphoma
Author(s) -
Wood Angela,
Angus Brian,
Kestevan Patrick,
Dark John,
Notarianni Giancarlo,
Miller Sue,
Howard Martin,
Proctor Steve,
Middleton Pete
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.2903110.x
Subject(s) - lymphoma , alpha interferon , gene , post transplant lymphoproliferative disorder , lymphoproliferative disorders , interferon alfa , chemotherapy , chromosome , cancer research , biology , medicine , immunology , interferon , genetics , rituximab
Post‐transplant lymphoproliferative disorder (PTLD) is a well‐recognized complication of organ transplant and has been associated with high mortality using conventional chemotherapy. We have investigated 11 cases of PTLD for alterations to the interferon alpha (IFNA) and p16 genes on chromosome 9p using archival material. 4/9 (44%) cases had deletions of the IFNA genes, in contrast to 1/59 (1.7%) cases of intermediate/high‐grade de novo NHL drawn from the same geographical region. PTLD may therefore represent a distinct NHL subgroup exhibiting distinct gene pathology.