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Successful second bone marrow transplant for Fanconi's anaemia following escalation of conditioning
Author(s) -
O'Donnell J.,
Roberts I.,
De La Fuente J.,
Daly P.,
New H.,
Dokal I.
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.2493066.x
Subject(s) - cyclophosphamide , conditioning regimen , medicine , conditioning , regimen , fanconi anemia , bone marrow , chemotherapy , bone marrow failure , oncology , bone marrow transplantation , sibling , immunology , stem cell , haematopoiesis , psychology , biology , biochemistry , statistics , genetics , mathematics , dna repair , gene , developmental psychology
Allogeneic bone marrow transplantation represents the treatment of choice for severe bone marrow failure in patients with Fanconi's anaemia (FA). In view of the increased sensitivity to alkylating agents documented in this condition, much attention has focused on reducing the conditioning chemotherapy. We present a 13‐year‐old girl in whom sibling allogeneic BMT after conditioning with low‐ dose cyclophosphamide only resulted in graft rejection. However, a second transplant using the same donor proved successful following a more intensive conditioning regimen. This case demonstrates the phenotypic variability of FA, and highlights the need for tailoring the conditioning regimen for a given patient.