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High serum levels of CA125 and interleukin‐6 in a patient with Ki‐1 lymphoma
Author(s) -
Kubonishi Ichiro,
Bandobashi Kentaro,
Murata Naoaki,
Daibata Masanori,
Ido Eiji,
Sonobe Hiroshi,
Ohtsuki Yuji,
Miyoshi Isao
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.2383054.x
Subject(s) - lymphoma , chemotherapy , medicine , interleukin , ovarian cancer , cancer research , immunology , cancer , cytokine
We report a 53‐year‐old‐man with an aggressive Ki‐1 lymphoma who had high serum CA125, a marker protein of the epithelial ovarian cancer, and interleukin‐6 (IL‐6) concentrations. Both CA125 and IL‐6 levels decreased after chemotherapy and elevated with disease progression. The patient's lymphoma cells obtained before chemotherapy grew continuously in vitro , were IL‐6 dependent and were found to secrete CA125 in culture medium. These results indicate that CA125 can be secreted by Ki‐1 lymphoma cells and IL‐6 may promote the growth of Ki‐1 lymphoma cells.