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Successive transformation of chronic myelomonocytic leukaemia into acute myeloblastic then lymphoblastic leukaemia, both with minor‐bcr rearrangement
Author(s) -
DAUTEL Marie Michèle,
FRANÇOIS Sylvie,
BERTHEAS MarieFranÇoise,
BARANGER Laurence,
GARDAIS Jacques,
BOASSON Marc,
IFRAH Norbert,
BLANCHET Odile
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.1692986.x
Subject(s) - breakpoint cluster region , breakpoint , philadelphia chromosome , medicine , cancer research , gene rearrangement , abl , chromosome , biology , chromosomal translocation , genetics , gene , receptor , tyrosine kinase
We report a case of chronic myelomonocytic leukaemia (CMML), which transformed first into acute myeloblastic leukaemia (AML) and then into acute lymphoblastic leukaemia (ALL). In the AML and ALL phases, chromosome analysis showed a classic Philadelphia chromosome (Ph) t(9;22)(q34;q11). Molecular studies showed breakpoint cluster region rearrangement between exons e1 and a2 compatible with a p190 bcr/abl breakpoint as observed in Ph‐positive lymphoblastic acute leukaemia. The minor (m‐bcr) rearrangement was also detected during complete remission. This observation supports a multistep pathogenesis of leukaemias, and that the p190 bcr/abl breakpoint may influence the course of the disease.