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Polymorphism of the tumour necrosis factor‐alpha and lymphotoxin‐alpha genes in hairy cell leukaemia
Author(s) -
Demeter Judith,
Porzsolt Franz,
RÄmisch Stephanie,
Schmid Mathias,
Messer Gerald
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.142657.x
Subject(s) - lymphotoxin alpha , lymphotoxin , tumor necrosis factor alpha , immunology , pancytopenia , alpha (finance) , necrosis , allele , biology , peripheral blood mononuclear cell , gene , cancer research , medicine , pathology , genetics , bone marrow , construct validity , nursing , patient satisfaction , in vitro
Hairy cell leukaemia (HCL) is a rare chronic B lymphoproliferative disorder which can lead to severe pancytopenia and several immunologic abnormalities. The pathogenetic role of tumour necrosis factor (TNF)‐α in HCL prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL. The TNF‐α (−308 bp) promoter/enhancer point mutation and two polymorphisms located within the first intron of the lymphotoxin (LT)‐α gene showed neither significant allelic deviation for the patient group nor, after analysis of clinical characteristics such as blood counts, stable or progressive disease or response to therapy.