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Bone mineralization and turnover in children with congenital neutropenia, and its relationship to treatment with recombinant human granulocyte‐colony stimulating factor
Author(s) -
Fewtrell M. S.,
Kinsey S. E.,
Williams D. M.,
Bishop N. J.
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.1302945.x
Subject(s) - congenital neutropenia , neutropenia , medicine , granulocyte colony stimulating factor , rickets , bone mineral content , granulocyte , recombinant dna , mineralization (soil science) , pediatrics , vitamin d and neurology , bone mineral , chemotherapy , chemistry , osteoporosis , biochemistry , organic chemistry , nitrogen , gene
Bone mineral content (BMC) of the radius was measured using single photon absorptiometry (SPA) in nine children with congenital neutropenia. Five had normal values. Two children with severe congenital neutropenia (SCN) had low BMC, and two boys with Schwachman syndrome had biochemistry suggestive of rickets.