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Novel and diagnostically applicable information from optical waveform analysis of blood coagulation in disseminated intravascular coagulation
Author(s) -
DOWNEY COLIN,
KAZMI RASHID,
TOH CHENG HOCK
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.1062972.x
Subject(s) - disseminated intravascular coagulation , partial thromboplastin time , medicine , coagulation , coagulation testing , fulminant , cardiology , intensive care medicine
Transmittance waveform is the term applied to the optical profile generated from the process of clot formation on standard coagulation tests run on the MDA‐180, a new‐generation automated coagulation analyser. In patients with disseminated intravascular coagulation, a characteristically abnormal ‘biphasic change’ is seen on both the activated partial thromboplastin time and thrombin time waveforms. Increasing steepness of the initial slope on the waveform correlates with clinical deterioration and fulminant progression. Although the mechanism underlying the biphasic appearance remains to be elucidated, its identification provides the diagnostic laboratory with a simple, rapid and robust assay for disseminated intravascular coagulation that can help the clinician with urgent and appropriate therapeutic interventions.