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Myelomonoblastic leukaemia cells carrying the PEBP2β/MYH11 fusion gene are CD34 + , c‐KIT + immature cells
Author(s) -
Osato Motomi,
Asou Norio,
Okubo Toshiya,
Nishimura Shintaro,
Yamasaki Hiroshi,
Era Takumi,
Suzushima Hitoshi,
Kawano Fumio,
Matsuoka Rumiko,
Oka Hiroya,
Bae SukChul,
Ito Yoshiaki,
Takatsuki Kiyoshi
Publication year - 1997
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1997.1012917.x
Subject(s) - fusion gene , biology , cd34 , microbiology and biotechnology , gene , immunophenotyping , antigen , genetics , stem cell
To clarify the aspects affected by the PEBP2β/MYH11 fusion gene involved in the inv(16), we analysed immunophenotypes in myelomonoblastic leukaemias. We found high expressions of CD34 and c‐KIT antigens in myelomonoblastic cells from all patients carrying this fusion gene, including two with M4 and one CML blastic phase, in contrast to those with M4 without the fusion gene. These findings indicate that immunophenotyping is useful for detecting a leukaemia with the fusion gene in myelomonoblastic leukaemias and that the PEBP2β/MYH11 gene is involved in immature cells expressing CD34 and c‐KIT antigens.