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Reversible bone marrow depression by high‐dose piperacillin/tazobactam
Author(s) -
RUIZIRASTORZA GUILLERMO,
BARREIRO GUILLERMO,
AGUIRRE CIRIACO
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1952.x
Subject(s) - piperacillin/tazobactam , medicine , piperacillin , tazobactam , bone marrow , depression (economics) , intensive care medicine , biology , genetics , macroeconomics , bacteria , economics , pseudomonas aeruginosa
Bone marrow toxicity, mainly neutropenia, has been described as an uncommon secondary effect of most beta‐lactams, and it is usually related to large cumulative doses. Although previously described for piperacillin, no cases of marrow depression caused by piperacillin/tazobactam have been reported to date. We report a case of reversible pancytopenia, with evidence of bone marrow depression, which occurred after a 17 d course of piperacillin/tazobactam. The drug was given to an underweight 18‐year‐old woman, at the usual dosage of 4/0.5 g three times a day. We stress the need for reducing the recommended dosage when treating underweight adult patients, and also of monitoring haematological parameters during prolonged treatments.