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Eosinophilia and granulocytic dysplasia terminating in acute myeloid leukaemia after 24 years
Author(s) -
Doorduijn J. K.,
van Lom K.,
Löwenberg B.
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1931.x
Subject(s) - trisomy 8 , eosinophilia , trisomy , pathology , myeloid , cytogenetics , karyotype , medicine , myeloid leukaemia , dysplasia , immunology , biology , chromosome , genetics , gene
Eosinophilia of variable duration, and subsequent progression to granulocytic sarcoma and acute myeloid leukaemia, has been infrequently reported in the literature. We report a patient with eosinophilia and normal cytogenetics who, after 24 years, showed transformation to a granulocytic sarcoma of the brain. Haematological counts were normal but the marrow revealed the cytogenetic abnormality trisomy 8 in 25% of mitoses. Subsequently an AML‐M2 developed, showing a complex karyotype including the trisomy 8 in all metaphases. FISH analysis combined with cytological examination identified the trisomy 8 in blasts, eosinophils and dysplastic granulocytes only. Thus progressive leukaemic transformation selectively involved the myeloid compartment.