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Circulating endothelial cell/leucocyte adhesion molecules in ischaemic heart disease
Author(s) -
BLANN ANDREW D.,
AMIRAL JEAN,
MCCOLLUM CHARLES N.
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1921.x
Subject(s) - von willebrand factor , thrombomodulin , medicine , asymptomatic , ischaemic heart disease , coronary artery disease , endothelium , cell adhesion molecule , p selectin , cardiology , endothelial stem cell , selectin , risk factor , disease , immunology , platelet , biology , inflammation , thrombin , platelet activation , biochemistry , in vitro
Increased levels of the endothelial markers soluble E‐selectin ( P = 0.011), soluble thrombomodulin ( P = 0.0001) and von Willebrand factor (VWF, P < 0.0001) were found in 116 patients with ischaemic heart disease compared to an equal number of age‐ and sex‐matched asymptomatic controls. In a multivariate analysis of the markers versus the major risk factors for atherosclerosis, VWF correlated with total cholesterol ( P = 0.002) and E‐selectin with sex (lower in women, P = 0.004) and triglycerides ( P = 0.007). The data point to profound differences in the release mechanisms of these three endothelial cell products and suggests that further studies into the roles of these molecules in coronary artery disease are warranted.