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Clonal identification of Burkitt's Lymphoma Arising from Lymphocyte‐Predominant Hodgkin's Disease
Author(s) -
Yoshinaga Haruhiko,
Ohashi Kazuteru,
Yamamoto Koh,
Miki Tohru,
Miura Osamu,
Saito Takako,
Koyama Takatoshi,
Kanazawa Akira,
Nemoto Tetsuo,
Miyasaka Nobuyuki,
Kamiyama Ryuichi,
Hirosawa Shinsaku
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1914.x
Subject(s) - lymphoma , polymerase chain reaction , lymphocyte , clone (java method) , pathology , lymph node , disease , lymph , biology , medicine , immunology , genetics , dna , gene
The occurrence of large cell lymphomas subsequent to, or concurrent with, lymphocyte predominant Hodgkin's disease (LPHD) is a well‐documented phenomenon. We present a case of Burkitt's lymphoma of the bladder, occurring after the successful treatment of LPHD of a cervical lymph node. To evaluate the clonal relationship of the two tumours, we amplified the complementarity‐determining‐region 3 of two samples from paraffin‐embedded slides, using the polymerase chain reaction (PCR). The sequences of the PCR products showed 96% homology to each other. These results indicate that the malignant clone of Burkitt's lymphoma arose from the corresponding LPHD.