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p190 bcr/abl rearrangement in myelodysplastic syndromes: two reports and review of the literature
Author(s) -
Lesesve J. F.,
Troussard X.,
Bastard C.,
Hurst J. P.,
Nouet D.,
Callat M. P.,
Lenormand B.,
Piguet H.,
Flandrin G.,
Macintyre E.
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1898.x
Subject(s) - breakpoint cluster region , philadelphia chromosome , breakpoint , chromosome , karyotype , cytogenetics , myelodysplastic syndromes , abl , chromosomal translocation , gene rearrangement , biology , cancer research , acute myeloblastic leukemia , genetics , medicine , leukemia , immunology , bone marrow , gene , signal transduction , tyrosine kinase
We describe two patients with myelodysplastic syndrome (MDS) and the Philadelphia chromosome (Ph). The patients were 64‐ and 69‐year‐old men who were diagnosed as having refractory anaemia with excess of blasts. During the terminal phase, the MDS evolved to myeloblastic leukaemia. Chromosome analysis showed normal karyotypes mixed with metaphases containing a classic Ph chromosome t(9;22)(q34;q11). Surprisingly, molecular studies showed breakpoint cluster region rearrangement between exons e1 and a2, compatible with a p190 bcr/abl breakpoint, as observed in acute lymphoblastic leukaemia. We discuss the correlation between MDS and acquisition of the Ph chromosome, and the occurrence of p190 bcr/abl in MDS.