Premium
Acute arterial thrombosis due to platelet aggregation in a patient receiving granulocyte colony‐stimulating factor
Author(s) -
Kawachi Yasunori,
Watanabe Ayako,
Uchida Tatsumi,
Yoshizawa Kiyoshi,
Kurooka Nobuaki,
Setsu Kojun
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1807.x
Subject(s) - platelet , medicine , thrombus , thrombosis , granulocyte colony stimulating factor , adenosine diphosphate , platelet activation , platelet aggregation , gastroenterology , immunology , chemotherapy
We describe a 44‐year‐old man with non‐Hodgkin's lymphoma receiving granulocyte colony‐stimulating factor (G‐CSF) who developed an acute arterial thrombosis. The removed thrombus contained large amounts of platelet aggregation. A rapid increase of platelets and increased adenosine diphosphate (ADP)‐ and collagen‐induced platelet aggregation were observed at the time of the thrombotic event. A challenge test of G‐CSF showed an increase in the platelet count and an augmentation of ADP‐ and collagen‐induced platelet aggregation. In the use of G‐CSF, patients who produce a rapid increase in platelet levels could be at greater risk for thrombotic events and need to be followed‐up carefully.